United States securities and exchange commission logo

                          January 4, 2024

       Helen Sabzevari
       President and Chief Executive Officer
       Precigen, Inc.
       20374 Seneca Meadows Parkway
       Germantown, Maryland 20876

                                                        Re: Precigen, Inc.
Statement on Form S-3
                                                            Filed December 29,
                                                            File No. 333-276337

       Dear Helen Sabzevari:

              This is to advise you that we have not reviewed and will not
review your registration

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Cindy
Polynice at 202-551-8707 with any questions.


                          Division of Corporation Finance

                          Office of Life Sciences
       cc:                                              Yasin Keshvargar, Esq.