United States securities and exchange commission logo

                          October 2, 2020

       Helen Sabzevari
       Chief Executive Officer
       Precigen, Inc.
       20374 Seneca Meadows Parkway
       Germantown, MD 20876

                                                        Re: Precigen, Inc.
Statement on Form S-3
                                                            Filed September 30,
                                                            File No. 333-249172

       Dear Ms. Sabzevari:

              This is to advise you that we have not reviewed and will not
review your registration

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Nicholas
Lamparski at (202) 551-4695 with any questions.


                          Division of Corporation Finance

                          Office of Trade & Services
       cc:                                              William Intner