0000001 - Document - Cover Page link:presentationLink link:calculationLink link:definitionLink 0000002 - Document - Audit Information link:presentationLink link:calculationLink link:definitionLink 9952151 - Statement - Consolidated Balance Sheets link:presentationLink link:calculationLink link:definitionLink 9952152 - Statement - Consolidated Balance Sheets (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952153 - Statement - Consolidated Statements of Operations link:presentationLink link:calculationLink link:definitionLink 9952154 - Statement - Consolidated Statements of Comprehensive Loss link:presentationLink link:calculationLink link:definitionLink 9952155 - Statement - Consolidated Statements of Mezzanine Equity and Shareholders' Equity link:presentationLink link:calculationLink link:definitionLink 9952156 - Statement - Consolidated Statements of Cash Flows link:presentationLink link:calculationLink link:definitionLink 9952157 - Statement - Consolidated Statements of Cash Flows (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952158 - Disclosure - Organization and Basis of Presentation link:presentationLink link:calculationLink link:definitionLink 9952159 - Disclosure - Summary of Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 9952160 - Disclosure - Product and Service Revenue and Reserves link:presentationLink link:calculationLink link:definitionLink 9952161 - Disclosure - Collaboration and Licensing Revenue link:presentationLink link:calculationLink link:definitionLink 9952162 - Disclosure - Short-term and Long-term Investments link:presentationLink link:calculationLink link:definitionLink 9952163 - Disclosure - Fair Value Measurements link:presentationLink link:calculationLink link:definitionLink 9952164 - Disclosure - Inventory link:presentationLink link:calculationLink link:definitionLink 9952165 - Disclosure - Property, Plant and Equipment, Net link:presentationLink link:calculationLink link:definitionLink 9952166 - Disclosure - Goodwill and Intangible Assets, Net link:presentationLink link:calculationLink link:definitionLink 9952167 - Disclosure - Debt link:presentationLink link:calculationLink link:definitionLink 9952168 - Disclosure - Income Taxes link:presentationLink link:calculationLink link:definitionLink 9952169 - Disclosure - Mezzanine Equity and Shareholders' Equity link:presentationLink link:calculationLink link:definitionLink 9952170 - Disclosure - Share-Based Payments link:presentationLink link:calculationLink link:definitionLink 9952171 - Disclosure - Operating Leases link:presentationLink link:calculationLink link:definitionLink 9952172 - Disclosure - Commitments and Contingencies link:presentationLink link:calculationLink link:definitionLink 9952173 - Disclosure - Segments link:presentationLink link:calculationLink link:definitionLink 9952174 - Disclosure - Defined Contribution Plans link:presentationLink link:calculationLink link:definitionLink 9955511 - Disclosure - Summary of Significant Accounting Policies (Policies) link:presentationLink link:calculationLink link:definitionLink 9955512 - Disclosure - Summary of Significant Accounting Policies (Tables) link:presentationLink link:calculationLink link:definitionLink 9955513 - Disclosure - Product and Service Revenue and Reserves (Tables) link:presentationLink link:calculationLink link:definitionLink 9955514 - Disclosure - Collaboration and Licensing Revenue (Tables) link:presentationLink link:calculationLink link:definitionLink 9955515 - Disclosure - Short-term and Long-term Investments (Tables) link:presentationLink link:calculationLink link:definitionLink 9955516 - Disclosure - Fair Value Measurements (Tables) link:presentationLink link:calculationLink link:definitionLink 9955517 - Disclosure - Inventory (Tables) link:presentationLink link:calculationLink link:definitionLink 9955518 - Disclosure - Property, Plant and Equipment, Net (Tables) link:presentationLink link:calculationLink link:definitionLink 9955519 - Disclosure - Goodwill and Intangible Assets, Net (Tables) link:presentationLink link:calculationLink link:definitionLink 9955520 - Disclosure - Debt (Tables) link:presentationLink link:calculationLink link:definitionLink 9955521 - Disclosure - Income Taxes (Tables) link:presentationLink link:calculationLink link:definitionLink 9955522 - Disclosure - Mezzanine Equity and Shareholders' Equity (Tables) link:presentationLink link:calculationLink link:definitionLink 9955523 - Disclosure - Share-Based Payments (Tables) link:presentationLink link:calculationLink link:definitionLink 9955524 - Disclosure - Operating Leases (Tables) link:presentationLink link:calculationLink link:definitionLink 9955525 - Disclosure - Segments (Tables) link:presentationLink link:calculationLink link:definitionLink 9955526 - Disclosure - Organization and Basis of Presentation (Details) link:presentationLink link:calculationLink link:definitionLink 9955527 - Disclosure - Summary of Significant Accounting Policies - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955528 - Disclosure - Summary of Significant Accounting Policies - Summary of Accounts Receivable, Allowance for Credit Losses (Details) link:presentationLink link:calculationLink link:definitionLink 9955529 - Disclosure - Summary of Significant Accounting Policies - Summary of Estimated Useful Lives of Property, Plant and Equipment (Details) link:presentationLink link:calculationLink link:definitionLink 9955530 - Disclosure - Summary of Significant Accounting Policies - Summary of Assumptions Used in Option Pricing Model (Details) link:presentationLink link:calculationLink link:definitionLink 9955531 - Disclosure - Summary of Significant Accounting Policies - Summary of Potentially Dilutive Securities Excluded from Calculation of Net Loss per Share (Details) link:presentationLink link:calculationLink link:definitionLink 9955532 - Disclosure - Product and Service Revenue and Reserves - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955533 - Disclosure - Product and Service Revenue and Reserves - Summary of Product and Service Revenue by Source (Details) link:presentationLink link:calculationLink link:definitionLink 9955534 - Disclosure - Collaboration and Licensing Revenue - Summary of Summarized Collaboration and Licensing Revenues (Details) link:presentationLink link:calculationLink link:definitionLink 9955535 - Disclosure - Collaboration and Licensing Revenue - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955536 - Disclosure - Collaboration and Licensing Revenue - Summary of Deferred Revenue (Details) link:presentationLink link:calculationLink link:definitionLink 9955537 - Disclosure - Short-term and Long-term Investments - Summary of Amortized Cost, Gross Unrealized Gains and Losses and Fair Value of Investments (Details) link:presentationLink link:calculationLink link:definitionLink 9955538 - Disclosure - Short-term and Long-term Investments - Summary of Contractual Obligation, Fiscal Year Maturity (Details) link:presentationLink link:calculationLink link:definitionLink 9955539 - Disclosure - Short-term and Long-term Investments - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955540 - Disclosure - Fair Value Measurements - Summary of Placement in the Fair Value Hierarchy of Financial Assets that are Measured at Fair Value on a Recurring Basis (Details) link:presentationLink link:calculationLink link:definitionLink 9955541 - Disclosure - Fair Value Measurements - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955542 - Disclosure - Fair Value Measurements and Warrant Liabilities - Summary of Changes in Fair Value of Warrant Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955543 - Disclosure - Inventory (Details) link:presentationLink link:calculationLink link:definitionLink 9955544 - Disclosure - Property, Plant and Equipment, Net - Summary of Property, Plant and Equipment (Details) link:presentationLink link:calculationLink link:definitionLink 9955545 - Disclosure - Property, Plant and Equipment, Net - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955546 - Disclosure - Goodwill and Intangible Assets, Net - Summary of Changes in Carrying Amount of Goodwill (Details) link:presentationLink link:calculationLink link:definitionLink 9955547 - Disclosure - Goodwill and Intangible Assets, Net - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955548 - Disclosure - Goodwill and Intangible Assets, Net - Summary of Intangible Assets (Details) link:presentationLink link:calculationLink link:definitionLink 9955549 - Disclosure - Goodwill and Intangible Assets, Net - Summary of Definite-Lived Intangible Assets, Estimated Future Amortization Expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955550 - Disclosure - Debt - Long Term Debt - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955551 - Disclosure - Debt - Schedule of Long Term Debt (Details) link:presentationLink link:calculationLink link:definitionLink 9955552 - Disclosure - Debt - Schedule of Interest Expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955553 - Disclosure - Debt - Lines of Credit - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955554 - Disclosure - Debt - Convertible Notes - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955555 - Disclosure - Debt - Schedule of Future Maturities of Long Term Debt (Details) link:presentationLink link:calculationLink link:definitionLink 9955556 - Disclosure - Income Taxes - Summary of Components of Loss Before Income Taxes (Details) link:presentationLink link:calculationLink link:definitionLink 9955557 - Disclosure - Income Taxes - Summary of Components of Income Tax Benefit (Details) link:presentationLink link:calculationLink link:definitionLink 9955558 - Disclosure - Income Taxes - Summary of Effective Income Tax Rate Reconciliation (Details) link:presentationLink link:calculationLink link:definitionLink 9955559 - Disclosure - Income Taxes - Summary of Deferred Tax Assets and Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955560 - Disclosure - Income Taxes - Summary of Valuation Allowance (Details) link:presentationLink link:calculationLink link:definitionLink 9955561 - Disclosure - Income Taxes - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955562 - Disclosure - Mezzanine Equity and Shareholders' Equity - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955563 - Disclosure - Mezzanine Equity and Shareholders' Equity - Summary of Components of Accumulated Other Comprehensive Income (Loss) (Details) link:presentationLink link:calculationLink link:definitionLink 9955564 - Disclosure - Share-Based Payments - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955565 - Disclosure - Share-Based Payments - Summary of Stock-Based Compensation Expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955566 - Disclosure - Share-Based Payments - Summary of Stock Option Activity (Details) link:presentationLink link:calculationLink link:definitionLink 9955567 - Disclosure - Share-Based Payments - Schedule of Additional Information About Stock Options Outstanding (Details) link:presentationLink link:calculationLink link:definitionLink 9955568 - Disclosure - Share-Based Payments - Summary of RSU And PSU Activity (Details) link:presentationLink link:calculationLink link:definitionLink 9955569 - Disclosure - Operating Leases - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955570 - Disclosure - Operating Leases - Summary of Components of Lease Costs (Details) link:presentationLink link:calculationLink link:definitionLink 9955571 - Disclosure - Operating Leases - Summary of Maturities of Lease Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955571 - Disclosure - Operating Leases - Summary of Maturities of Lease Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955572 - Disclosure - Operating Leases - Summary of Lease Terms and Discount Rates (Details) link:presentationLink link:calculationLink link:definitionLink 9955573 - Disclosure - Operating Leases - Summary of Other Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955574 - Disclosure - Commitments and Contingencies (Details) link:presentationLink link:calculationLink link:definitionLink 9955575 - Disclosure - Segments - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955576 - Disclosure - Segments - Summary of Segment Net Loss (Details) link:presentationLink link:calculationLink link:definitionLink 9955577 - Disclosure - Defined Contribution Plans (Details) link:presentationLink link:calculationLink link:definitionLink